LABORATÓRIO DE METABOLÔMICA

SOBRE

O LABMETA tem como foco principal a análise metabolômica de diferentes matrizes biológicas utilizando a cromatografia líquida acoplada a espectrometria de massas de alta resolução. O laboratório emprega diferentes ferramentas de quimio- e bioinformática e análise multivariada de dados. Também desenvolve projetos na área de fontes de ionização ambiente na espectrometria de massas. O laboratório abrange conhecimentos de diferentes áreas da ciência, reunindo profissionais de diferentes perfis.

Distúrbio do Metabolismo humano

Busca de novos marcadores químicos para diagnóstico rápido e simples de doenças de depósito lisossomal, como mucopolissacaridoses e doença de Pompe.

Técnicas de Ionização

Desenvolvimento e aplicação de fontes de ionização ambiente na espectrometria de massas para análise direta de diferentes tipos de amostras.

Produtos Naturais

Estudo de desreplicação de produtos naturais e alimentos empregando técnicas modernas de análise metabolômica e tratamento de dados, como as Redes Moleculares.

Determinação de Massa Exata

Análise por espectrometria de massas de alta resolução e exatidão em massas para compostos de baixa massa molecular em produtos de síntese, metabólitos primários e secundários de origem natural, alimentos, etc.

Desenvolvimento de Métodos

Análise exploratória de misturas complexas empregando a cromatografia líquida de ultra performance acoplada à espectrometria de massas de alta resolução e exatidão em massas.

GALERIA

Todas as ômicas em um mesmo lugar.
Conheça o NEMO e turbine sua pesquisa.

Publicações LABMETA

Publicações LABMETA

DE FREITAS SILVA, MATHEUS ; JULIET CRISTANCHO ORTIZ, CINDY ; FERREIRA COELHO, LETÍCIA ; PRUCCOLI, LETIZIA ; PAGLIARANI, BARBARA ; PISANI, LEONARDO ; CATTO, MARCO ; POLI, GIULIO ; TUCCINARDI, TIZIANO ; CARDOSO VILELA, FABIANA ; GIUSTI-PAIVA, ALEXANDRE ; AMARAL ALVES, MARINA ; RIBEIRO DE SOUZA, HYGOR M. ; TAROZZI, ANDREA ; SILVA GONTIJO, VANESSA ; VIEGAS, CLAUDIO . Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinsons disease. BIOORGANIC CHEMISTRY, v. 150, p. 107587, 2024. 

 

DE SOUZA, HYGOR M. R. ; PEREIRA, TÁSSIA T. P. ; DE SÁ, HANNA C. ; ALVES, MARINA A. ; GARRETT, Rafael ; CANUTO, GISELE A. B. . Critical Factors in Sample Collection and Preparation for Clinical Metabolomics of Underexplored Biological Specimens. METABOLITES, v. 14, p. 36, 2024. 

 

SOUTO, LUÍS FERNANDO L. ; BORGES, RICARDO MOREIRA ; DA COSTA, RAFAEL GARRETT ; DOS SANTOS, RAILANE INÁCIO L. ; DA SILVA, ANTÔNIO JORGE RIBEIRO . Dereplication of calystegines in food plants and wild Solanum Brazilian fruits. FOOD CHEMISTRY, v. 446, p. 138808, 2024.  

 

NETO, DOMINGOS F. M. ; GARRETT, Rafael ; DOMONT, GILBERTO B. ; CAMPOS, FRANCISCO A. P. ; NOGUEIRA, FÁBIO C. S. . Untargeted Metabolomic Analysis of Leaves and Roots of Jatropha curcas Genotypes with Contrasting Levels of Phorbol Esters. PHYSIOLOGIA PLANTARUM, v. 176, p. e14274, 2024.  

 

AZEVEDO, PEDRO HENRIQUE R. DE A. ; CAMARGO, PRISCILA G. ; CONSTANT, LARISSA E. C. ; COSTA, STEPHANY DA S. ; SILVA, CELIMAR SINÉZIA ; ROSA, ALICE S. ; SOUZA, DANIEL D. C. ; TUCCI, AMANDA R. ; FERREIRA, VIVIAN N. S. ; OLIVEIRA, THAMARA KELCYA F. ; BORBA, NATHALIA R. R. ; RODRIGUES, CARLOS R. ; ALBUQUERQUE, MAGALY G. ; DIAS, LUIZA R. S. ; GARRETT, Rafael ; MIRANDA, MILENE D. ; ALLONSO, DIEGO ; LIMA, CAMILO HENRIQUE DA S. ; MURI, ESTELA MARIS F. . Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV-2 Mpro). Scientific Reports, v. 14, p. 8991, 2024.  

 

PEREIRA, CAMILA ; MELO, MICHELLE ; DE CAMPOS, VANIA ; PEREIRA, IVANIA ; OLIVEIRA, ADRIANA ; ROCHA, MARIANA ; BATISTA, JOÃO VITOR ; PAES DE ALMEIDA, VALTER ; MONCHAK, IRAILSON ; RICCI-JÚNIOR, EDUARDO ; GARRETT, Rafael ; CARVALHO, ALINE ; MANFRON, JANE ; BAUMGARTNER, STEPHAN ; HOLANDINO, CARLA . Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm. International Journal of Nanomedicine, v. Volume 19, p. 5953-5972, 2024. 

 

PASSOS, CARLOS LUAN ALVES ; FERREIRA, CHRISTIAN ; CARVALHO, ALINE GABRIELLE ALVES DE ; SILVA, JERSON LIMA ; GARRETT, Rafael ; FIALHO, ELIANE . Oxyresveratrol in Breast Cancer Cells: Synergistic Effect with Chemotherapeutics Doxorubicin or Melphalan on Proliferation, Cell Cycle Arrest, and Cell Death. PHARMACEUTICS, v. 16, p. 873, 2024.  

 

DE ASSIS, JULIANE LOPES ; GRELLE, GLORIA MARIA RAMALHO SOARES ; FERNANDES, ALINE MARIE ; DA SILVA ANICETO, BÁRBARA ; POMPEU, PEDRO ; DE MELLO, FABIANA VIEIRA ; GARRETT, Rafael ; VALVERDE, RAFAEL HOSPODAR FELIPPE ; EINICKER-LAMAS, MARCELO . Sphingosine 1-phosphate protective effect on human proximal tubule cells submitted to an in vitro ischemia model: the role of JAK2/STAT3. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, v. x, p. 1-13, 2024. 

 

MINHO, ALAN SILVA ; ALMEIDA, PAMELA GOMES DE ; KATO, NATÁLIA NAOMI ; BRAND, ANA LAURA MACEDO ; VIEIRA, ROBERTO FONTES ; GARRETT, Rafael ; LOPES, NORBERTO PEPORINE ; REZENDE, CLAUDIA MORAES ; FERNANDES, PATRICIA DIAS . Anti-Inflammatory, Antinociceptive, and LC-MS Metabolic Profile from Pseudotrimezia juncifolia (Klatt) Lovo & A. Gil. PHARMACEUTICALS, v. 17, p. 1101, 2024. 

 

GARRETT, Rafael; PTOLEMY, ADAM S ; PICKETT, SARA ; KELLOGG, MARK D ; PEAKE, ROY W A . Untargeted Metabolomics for Inborn Errors of Metabolism: Development and Evaluation of a Sustainable Reference Material for Correcting Inter-Batch Variability. Clinical Chemistry, v. hvae14, p. 1-11, 2024. 

 

DA SILVA OLIVEIRA, JOANA PAULA ; GARRETT, Rafael ; KOBLITZ, MARIA GABRIELA BELLO ; MACEDO, ANDREA FURTADO . Integrated targeted and untargeted metabolomics profiling of Vanilla species from the Atlantic Forest: Unveiling the bioeconomic potential of Vanilla cribbiana. FOOD CHEMISTRY, v. x, p. 141650, 2024. 

  

DOS SANTOS CASTRO, GLEUCINEI ; FERNANDES SOUSA, THIAGO ; JARLINE SANTOS DA SILVA, INGRIDE ; SENA RAPOSO, DÉBORA ; CARLOS IPUCHIMA DA SILVA, JOSÉ ; PEÑALOZA, EVELYN ; GARRETT, Rafael ; EDUARDO BELEZA YAMAGISHI, MICHEL ; FERREIRA DA SILVA, GILVAN ; HENRIQUE FERREIRA KOOLEN, HECTOR . Amazonins: New Peptaibol Sequences from an Endophytic Strain ofTrichoderma amazonicum. CHEMISTRY & BIODIVERSITY, v. e20240, p. 1-8, 2024. 

 

PTOLEMY, A ; KIM, Y ; MACDONALD, C ; GARRETT, R ; KELLOGG, M ; PEAKE, R . A-316 A quantitative gas chromatography tandem mass spectrometry method for metabolic profiling of urine organic acids and acylglycines. CLINICAL CHEMISTRY, v. 70, p. 1-2, 2024. 

 

PTOLEMY, A ; PICKETT, S ; GARRETT, R ; GUARINO, B D ; KELLOGG, M ; PEAKE, R . A-317 Development of a patient-focused volumetric absorptive microsampling strategy to assess urinary amino acid excretion. CLINICAL CHEMISTRY, v. 70, p. i119, 2024. 

 

GUARINO, B ; PICKETT, S ; GARRETT, R ; KELLOGG, M ; PEAKE, R W ; PTOLEMY, A S . B-156 Extraction strategy for therapeutic drug monitoring of sirolimus and tacrolimus using volumetric absorptive microsampling. CLINICAL CHEMISTRY, v. 70, p. i197, 2024. 

 

ALMEIDA, MARIANA M. ; CALVIÑO, CAMILA ; REIS-GOMES, CLARA F. ; LOMBARDI, ISABELLE ; BRAND, ANA LAURA MACEDO ; PAZOS-MOURA, CARMEN C. ; GARRETT, Rafael ; ALVES, MARINA A. ; TREVENZOLI, ISIS H. . Maternal obesity changes the small intestine endocannabinoid system and fecal metabolites of weanling rats associated with reduced intestinal permeability and impaired glucose homeostasis. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 136, p. 109802, 2024. 

 

TORRES, CLARISSE L. ; SCALCO, FERNANDA B. ; DE OLIVEIRA, MARIA LÚCIA C. ; PEAKE, ROY W.A. ; GARRETT, Rafael . Untargeted LC-HRMS metabolomics reveals candidate biomarkers for mucopolysaccharidoses. CLINICA CHIMICA ACTA, v. 541, p. 117250, 2023.  

 

DE MORAES, MARIANA B. M. ; DE SOUZA, HYGOR M. R. ; DE OLIVEIRA, MARIA L. C. ; PEAKE, ROY W. A. ; SCALCO, FERNANDA B. ; GARRETT, Rafael . Combined targeted and untargeted high-resolution mass spectrometry analyses to investigate metabolic alterations in pompe disease. METABOLOMICS. (DORDRECHT. PRINT), v. 19, p. 29, 2023.  

 

MELO, MICHELLE NONATO DE OLIVEIRA ; BATISTA, JOÃO VITOR DA COSTA ; PEÑALOZA, EVELYN MARIBEL CONDORI ; OLIVEIRA, ADRIANA PASSOS ; GARRETT, Rafael ; BAUMGARTNER, STEPHAN ; HOLANDINO, CARLA . A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts. PLANTS, v. 12, p. 1811, 2023.  

 

COSTA, SARA NÁLLIA DE OLIVEIRA ; SILVA, MARCOS VINICIUS TOLEDO E ; RIBEIRO, JULIANA MARTINS ; CASTRO, JOSÉ MAURO DA CUNHA E ; MUZITANO, MICHELLE FRAZÃO ; COSTA, RAFAEL GARRETT DA ; OLIVEIRA, ANTÔNIA ELENIR AMÂNCIO ; FERNANDES, KÁTIA VALEVSKI SALES . Secondary metabolites related to the resistance of Psidium spp. against the nematode Meloidogyne enterolobii. HELIYON, v. 9, p. e17778, 2023.  

 

GAMA-ALMEIDA, MARCOS C. ; PINTO, GABRIELA D. A. ; TEIXEIRA, LÍVIA ; HOTTZ, EUGENIO D. ; IVENS, PAULA ; RIBEIRO, HYGOR ; GARRETT, Rafael ; TORRES, ALEXANDRE G. ; CARNEIRO, TALITA I. A. ; BARBALHO, BIANCA DE O. ; LUDWIG, CHRISTIAN ; STRUCHINER, CLAUDIO J. ; ASSUNÇÃO-MIRANDA, IRANAIA ; VALENTE, ANA PAULA C. ; BOZZA, FERNANDO A. ; BOZZA, PATRÍCIA T. ; DOS SANTOS, GILSON C. ; EL-BACHA, TATIANA . Integrated NMR and MS Analysis of the Plasma Metabolome Reveals Major Changes in One-Carbon, Lipid, and Amino Acid Metabolism in Severe and Fatal Cases of COVID-19. METABOLITES, v. 13, p. 879, 2023.  

 

DE SOUZA, HYGOR M. R. ; SCALCO, FERNANDA B. ; GARRETT, Rafael ; DE C. MARQUES, FLÁVIA F. . Development of a kit for urine collection on filter paper as an alternative for Pompe disease screening and monitoring by LC-HRMS. Analytical Methods, v. 15, p. 3932-3939, 2023.  

 

BRAND, A. L. M. ; LIMA, F. A. ; TINOCO, N. A. B. ; MOTA, J. C. ; MOREIRA, I. G. S. ; NOVAES, F. J. M. ; GARRETT, R. ; GIORNO, T. B. S. ; FERNANDES, P. D. ; REZENDE, C. M. . - N -Alkanoyl-5-Hydroxytryptamines (C n -5HTs) in Coffee: A Review. FOOD REVIEWS INTERNATIONAL, v. 39, p. 4761-4780, 2023.  

 

ALMEIDA, LANA R. ; MASTELLA, ANA MARIA O. ; ALVES, MARINA A. ; GARRET, RAFAEL ; PEREIRA, MARIA JOÃO R. . Do fecal bile acid analyses allow taxonomic discrimination between Neotropical mustelids?. Notas sobre Mamíferos Sudamericanos, v. 05, p. 001-007, 2023.  

 

BRAND, ANA LAURA M. ; SILVA, ANA CAROLINA R. ; GARRETT, Rafael ; Rezende, Claudia M. . Quantitative lipidomics in green robusta coffees from the Brazilian Amazon by LC-HRMS. Food Bioscience, v. 57, p. 103472, 2023.  

 

DE SOUZA WUILLDA, ALINE CAMARGO JESUS ; DAS NEVES COSTA, FERNANDA ; GARRETT, Rafael ; DOS SANTOS DE CARVALHO, MAURO ; BORGES, RICARDO MOREIRA . High-speed countercurrent chromatography with offline detection by electrospray mass spectrometry and nuclear magnetic resonance detection as a tool to resolve complex mixtures: A practical approach using Coffea arabica leaf extract. PHYTOCHEMICAL ANALYSIS, v. 35, p. 40-52, 2023. 

 

PTOLEMY, A S ; YOUNG, K ; MACDONALD, C ; GARRETT, R ; KELLOGG, M ; PEAKE, R W . B-201 Development of a Quantitative Gas Chromatography Tandem Mass Spectrometry Method for Metabolic Profiling of Urine Organic Acids. CLINICAL CHEMISTRY, v. 69, p. hvad097.530, 2023. 

 

DA SILVA OLIVEIRA, JOANA PAULA ; GARRETT, Rafael ; BELLO KOBLITZ, MARIA GABRIELA ; FURTADO MACEDO, ANDREA . Vanilla flavor: Species from the Atlantic forest as natural alternatives. FOOD CHEMISTRY, v. 375, p. 131891, 2022.  

 

SILVA, ANA CAROLINA R. ; GARRETT, Rafael ; REZENDE, C. M. ; MECKELMANN, SVEN W. . Lipid characterization of arabica and robusta coffee beans by liquid chromatography-ion mobility-mass spectrometry. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, v. 111, p. 104587, 2022.  

 

LOPES, ALINE GOMES ; BORGES, RICARDO MOREIRA ; KUHN, STEFAN ; GARRETT, Rafael ; COSTA, FERNANDA DAS NEVES . Combining high-speed countercurrent chromatography three-phase solvent system with electrospray ionization-mass spectrometry and nuclear magnetic resonance to profile the unconventional food plant Syzygium malaccense. JOURNAL OF CHROMATOGRAPHY A, v. 1677, p. 463211, 2022.  

 

DI MICELI, JERUZA FERRAZ FILGUEIRAS ; ANDRADE, MARIA EMÍLIA RABELO ; CARVALHO, PAULA LOPES ARMOND ; SANTOS, ELANDIA APARECIDA ; FARIA MOTA OLIVEIRA, ANNA ELIZA MACIEL DE ; FERNANDES, CAIO PINHO ; CRUZ, RODRIGO ALVES SOARES ; GARRETT, Rafael ; MOSQUEIRA, VANESSA CARLA FURTADO ; CASSALI, GEOVANNI DANTAS ; D'HAESE, CECILE ; NYSTEN, BERNARD ; LEITE, JACQUELINE ISAURA ALVAREZ ; CARDOSO, VALBERT NASCIMENTO ; ARAÚJO, RAQUEL SILVA . Lecithin-based nanocapsule loading sucupira (Pterodon emarginatus) oil effects in experimental mucositis. TOXICOLOGY REPORTS, v. 9, p. 1537-1547, 2022.  

 

MACEDO VAZ, SARAH ; DE FREITAS SILVA, MATHEUS ; DOS REIS ROSA FRANCO, GRAZIELLA ; JORGE R. GUIMARÃES, MARCOS ; MOTTA R. DA SILVA, FERNANDA ; GONÇALVES CASTRO, NEWTON ; ALVIM GUEDES, ISABELLA ; DARDENNE, LAURENT E. ; AMARAL ALVES, MARINA ; GARRETT DA COSTA, RAFAEL ; BESERRA PINHEIRO, GABRIELA ; GERMINO VERAS, LETÍCIA ; RENATA MORTARI, MÁRCIA ; PRUCCOLI, LETIZIA ; TAROZZI, ANDREA ; VIEGAS, CLÁUDIO . Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer?s disease. BIOORGANIC & MEDICINAL CHEMISTRY, v. 71, p. 116952, 2022.  

 

PASSOS MANSOLDO, FELIPE RAPOSO ; GARRETT, Rafael ; DA SILVA CARDOSO, VERONICA ; ALVES, MARINA AMARAL ; VERMELHO, ALANE BEATRIZ . Metabology: Analysis of metabolomics data using community ecology tools. ANALYTICA CHIMICA ACTA, v. 1232, p. 340469, 2022.  

 

MELO, MICHELLE NONATO DE OLIVEIRA ; OCHIONI, ALAN CLAVELLAND ; ZANCAN, PATRICIA ; OLIVEIRA, ADRIANA PASSOS ; GRAZI, MIRIO ; GARRETT, Rafael ; HOLANDINO, CARLA ; BAUMGARTNER, STEPHAN . Viscum album mother tinctures: Harvest conditions and host trees influence the plant metabolome and the glycolytic pathway of breast cancer cells. Frontiers in Pharmacology, v. 13, p. 1-18, 2022.  

 

DUARTE, JORGE ANDRÉS ; ALVES-RIBEIRO, GABRIELLE ; MACHADO, FRANCISCO PAIVA ; FOLLY, DIOGO ; PEÑALOZA, EVELYN ; GARRET, RAFAEL ; SANTOS, Marcelo Guerra ; VENTURA, JOSÉ AIRES ; WERMELINGER, GUILHERME FREIMANN ; ROBBS, BRUNO KAUFMANN ; ROCHA, Leandro ; FIAUX, SORELE BATISTA . Glimpsing the chemical composition and the potential of Myrtaceae plant extracts against the food spoilage fungus Thielaviopsis ethacetica. FOOD CONTROL, v. 146, p. 109501, 2022.  

 

BARROS, SUSY ÉRIKA DE LIMA ; DE LIMA, HENRIQUE BARROS ; GONÇALVES, LEANDRA KAROLINE ALVES ; CORREIA, LENIR CABRAL ; BRITO, MAIARA DE FÁTIMA DE BRITO ; BARCELOS, MARIANA PEGRUCCI ; SILVA, GUILHERME MARTINS ; DA SILVA, CARLOS HENRIQUE TOMICH DE PAULA ; DA COSTA, RAFAEL GARRETT ; CRUZ, RODRIGO ALVES SOARES ; CARVALHO, JOSÉ CARLOS TAVARES ; DA SILVA HAGE-MELIM, LORANE IZABEL . Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran. Toxicology Research, v. 11, p. 520-528, 2022. 

 

ALMEIDA, LANA RESENDE DE ; ALVES, MARINA AMARAL ; MASTELLA, ANA MARIA OBINO ; GARRETT, Rafael ; PEREIRA, MARIA JOÃO RAMOS . Neotropical mustelids: fecal metabolome diversity and its potential for taxonomic discrimination. Integrative Zoology, v. 18, p. 518-529, 2022.   

 

SILVA, M. V. T. E. ; GARRETT, Rafael ; GARRETT, Rafael ; SIMAS, D. L. R. ; KONNO, T. U. ; MUZITANO, M. F. ; PINTO, S. C. ; BARTH, T. . Chemical profile of Stachytarpheta schottiana by LC-HRMS/MS dereplication and molecular networking. Rodriguesia, v. 72, p. 1-11, 2021.  

 

MAURO, APARECIDA CRISTINA ; RIBEIRO, BERNARDO DIAS ; GARRETT, Rafael ; BORGES, RICARDO MOREIRA ; DA SILVA, TALIS UELISSON ; DE PAULA MACHADO, SÉRGIO ; DE ARAUJO, JOYCE RODRIGUES ; DE OLIVEIRA MASSAFRA, SANAIR ; DE OLIVEIRA JUNIOR, FRANCISCO ODENCIO RODRIGUES ; D?ELIA, ELIANE . Ziziphus joazeiro Stem Bark Extract as a Green Corrosion Inhibitor for Mild Steel in Acid Medium. PROCESSES, v. 9, p. 1323, 2021. 

 

JÄGER, TIM ; HOLANDINO, CARLA ; MELO, MICHELLE ; PEÑALOZA, EVELYN ; OLIVEIRA, ADRIANA ; GARRETT, Rafael ; GLAUSER, GAÉTAN ; GRAZI, MIRIO ; RAMM, HARTMUT ; URECH, KONRAD ; BAUMGARTNER, STEPHAN . Metabolomics by UHPLC-Q-TOF Reveals Host Tree-Dependent Phytochemical Variation in Viscum album L.. PLANTS, v. 10, p. 1726, 2021.  

 

ALVES, MARINA ; DA SILVA, ANA CAROLINA ; TORRES, CLARISSE ; DE ALMEIDA, LANA ; MASTELLA, ANA MARIA ; BORGES, RICARDO ; GARRETT, Rafael . A Systematic Pipeline to Enhance the Fecal Metabolome Coverage by LC-HRMS. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 32, p. 1435-1446, 2021.  

 

TORRES, CLARISSE ; SARDELA, VINICIUS ; SCALCO, FERNANDA ; AQUINO, FRANCISCO ; GARRETT, Rafael . DEVELOPMENT AND APPLICATION OF A TEST MIXTURE FOR UNTARGETED LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF URINE SAMPLES. QUÍMICA NOVA (ONLINE), v. 45, p. 89-96, 2021.  

 

BORGES, RICARDO ; RESENDE, JOÃO ; MORAES, ALDEBARAN ; PEREIRA, ALANA ; GARRETT, Rafael ; BAUERMEISTER, ANELIZE ; SILVA, ANTONIO . GUIA PARA PROCESSAMENTO DE DADOS DE CROMATOGRAFIA ACOPLADA A ESPECTROMETRIA DE MASSAS. QUÍMICA NOVA (ONLINE), v. 45, p. 608-620, 2021.  

 

SILVA, LAÍS DE O. ; GARRETT, Rafael ; MONTEIRO, MARIA LÚCIA G. ; CONTE-JUNIOR, CARLOS A. ; TORRES, ALEXANDRE G. . Pomegranate (Punica granatum) peel fractions obtained by supercritical CO2 increase oxidative and colour stability of bluefish (Pomatomus saltatrix) patties treated by UV-C irradiation. FOOD CHEMISTRY, v. 362, p. 130159, 2021.  

 

MENDES RESENDE, JOÃO VICTOR ; DE SÁ, NAJLA M.D. ; DE OLIVEIRA, MARCELO TROVÓ LOPES ; LOPES, ROSANA CONRADO ; GARRETT, Rafael ; MOREIRA BORGES, RICARDO . Chemical profiling of herbarium samples of solanum (Solanaceae) using mass spectrometry. Phytochemistry Letters, v. 36, p. 99-105, 2020.  

  

LOMBO VIDAL, OSCAR ; TSUKUI, ANNA ; GARRETT, Rafael ; MIGUEZ ROCHA-LEÃO, MARIA HELENA ; PILER CARVALHO, CARLOS WANDERLEI ; PEREIRA FREITAS, SUELY ; MORAES DE REZENDE, CLAUDIA ; SIMÕES LARRAZ FERREIRA, MARIANA . Production of bioactive films of carboxymethyl cellulose enriched with green coffee oil and its residues. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v. 146, p. 730-738, 2020.  

 

SIMAS PEREIRA JUNIOR, LUIZ CARLOS ; CORIOLANO DE OLIVEIRA, EDUARDO ; VALLE RORIG, TAÍSA DALLA ; PINTO DE ARAÚJO, PAULA IVENS ; SANCHEZ, ELÁDIO FLORES ; GARRETT, Rafael ; PALAZZO DE MELLO, JOÃO CARLOS ; FULY, ANDRÉ LOPES . The plant Stryphnodendron adstringens (Mart.) Coville as a neutralizing source against some toxic activities of Bothrops jararacussu snake venom. TOXICON, v. 186, p. 189-190, 2020.  

 

PEÑALOZA, EVELYN ; HOLANDINO, CARLA ; SCHERR, CLAUDIA ; ARAUJO, PAULA I. P. DE ; Borges, Ricardo M. ; URECH, KONRAD ; BAUMGARTNER, STEPHAN ; GARRETT, Rafael . Comprehensive Metabolome Analysis of Fermented Aqueous Extracts of Viscum album L. by Liquid Chromatography−High Resolution Tandem Mass Spectrometry. MOLECULES, v. 25, p. 4006, 2020.  

 

DOS SANTOS, DÉBORA N. ; PEDROSA, IGOR V. ; FERNANDES, CÉLIA R. R. ; LACHGAR, ABDOU ; NELI, MARCIO ; GARRETT, Rafael ; LAM, YIU LAU ; PEREIRA, MARCELO M. . Catalytic sugarcane bagasse transformation into a suitable biocrude for hydrocarbon production in typical refinery processes. Sustainable Energy & Fuels, v. 4, p. 4158-4169, 2020.  

 

SILVA, ANA CAROLINA R. ; DA SILVA, CAROL CRISTINE ; GARRETT, Rafael ; Rezende, Claudia M. . Comprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS. FOOD RESEARCH INTERNATIONAL, v. 137, p. 109727, 2020.  

 

HOLANDINO, CARLA ; MELO, MICHELLE NONATO DE OLIVEIRA ; OLIVEIRA, ADRIANA PASSOS ; BATISTA, JOÃO VITOR DA COSTA ; CAPELLA, MARCIA ALVES MARQUES ; GARRETT, Rafael ; GRAZI, MIRIO ; RAMM, HARTMUT ; TORRE, CLAUDIA DALLA ; SCHALLER, GERHARD ; URECH, KONRAD ; WEISSENSTEIN, ULRIKE ; BAUMGARTNER, STEPHAN . Phytochemical analysis and in vitro anti-proliferative activity of Viscum album ethanolic extracts. BMC Complementary Medicine and Therapies, v. 20, p. 215, 2020.  

 

 JÄGER, TIM ; HOLANDINO, CARLA ; GLAUSER, GAÉTAN ; GRAZI, MIRIO; RAMM, HARTMUT ; MELO, MICHELLE NONATO DE OLIVEIRA ; OLIVEIRA, ADRIANA PASSOS; GARRETT, Rafael ; BAUMGARTNER, STEPHAN . Metabolic profiling as a tool for differentiating Viscum album ssp. album plants growing on various host trees. PHYTOMEDICINE, v. 61., p. 1-2, 2019. 

 

SOARES, VITOR ; TAUJALE, RAHIL ; GARRETT, Rafael ; DA SILVA, ANTONIO JORGE R. ; Borges, Ricardo M. . Extending compound identification for molecular network using the LipidXplorer database independent method: A proof of concept using glycoalkaloids from Solanum pseudoquina A. St.-Hil.. PHYTOCHEMICAL ANALYSIS, v. 30, p. 132-138, 2019.  

 

DE SOUZA, ACÁCIO S. ; PACHECO, BARBARA D.C. ; PINHEIRO, SERGIO ; MURI, ESTELA M.F. ; DIAS, LUIZA R.S. ; LIMA, CAMILO H.S. ; GARRETT, Rafael ; DE MORAES, MARIANA B.M. ; DE SOUZA, BRUNO E.G. ; PUZER, LUCIANO . 3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 29, p. 1094-1098, 2019.  

 

FERNANDES, CAIO MACHADO ; FERREIRA FAGUNDES, THAYSSA DA S. ; ESCARPINI DOS SANTOS, NAZIR ; SHEWRY DE M. ROCHA, TALITA ; GARRETT, Rafael ; BORGES, RICARDO MOREIRA ; MURICY, GUILHERME ; VALVERDE, ALESSANDRA LEDA ; PONZIO, EDUARDO ARIEL . Ircinia strobilina crude extract as corrosion inhibitor for mild steel in acid medium. ELECTROCHIMICA ACTA, v. 312, p. 137-148, 2019.  

 

TSUKUI, ANNA ; VENDRAMINI, PEDRO H. ; GARRETT, Rafael ; Scholz, Maria Brígida S. ; Eberlin, Marcos N. ; BIZZO, HUMBERTO R. ; Rezende, Claudia M. . Direct-infusion electrospray ionization-mass spectrometry analysis reveals atractyligenin derivatives as potential markers for green coffee postharvest discrimination. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 103, p. 205-211, 2019.  

 

FERREIRA, I. Q. ; FERRAZ, T. O. ; ARAUJO, R. S. ; CRUZ, RODRIGO A.S. ; FERNANDES, CAIO MACHADO ; GARRETT, Rafael ; CARVALHO, J. C. T. ; OLIVEIRA, A. E. M. F. M. . Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio). PHARMACEUTICALS, v. 12, p. 175, 2019.  

 

DE SOUZA, MATHEUS O. ; GARRETT, Rafael ; PEREIRA, MARCELO M. ; MIRANDA, LEANDRO S. M. . Use of Kappaphycus alvarezii Biomass for the Production of Carbohydrate Isopropylidene-Ketal-Based Biocrude. ENERGY & FUELS, v. 31, p. 9422-9428, 2017.  

Coordenação

Rafael Garrett da Costa

Possui graduação em Farmácia com especialização em Indústria pela Universidade Federal Fluminense (2007), mestrado em Química de Produtos Naturais pelo Instituto de Pesquisas em Produtos Naturais/UFRJ (2010) e doutorado em Química pelo Instituto de Química/UFRJ (2014), com doutorado-sanduíche no Centre for Research in Mass Spectrometry, York University/Canadá. Realizou Pós-doutorado no Instituto de Química da UFRJ. Atualmente, é Professor Adjunto do Departamento de Química Orgânica do IQ/UFRJ e coordenador do Laboratório de Metabolômica (LabMeta-LADETEC/IQ-UFRJ). Faz parte do Programa de Pós-Graduação em Química da UFRJ (PGQu). Tem experiência nas áreas de Espectrometria de Massas, Cromatografia, Análise de fluidos biológicos, Química de Alimentos (café) e de Produtos Naturais, atuando, principalmente, nos seguintes temas: Metabolômica, Espectrometria de Massas de alta resolução, LC-MS/MS, desreplicação, Ionização ambiente.

Contato: rafael_garrett@iq.ufrj.br